反应 #452486

反应方程式

1-benzyl-4-(2-quinolylcarbonyl)piperazine hydrochloride

→

title compound

收率 77.7%

1-(2-quinolylcarbonyl)piperazine hydrochloride

收率 77.7%

溶剂

water

反应条件

后处理

1. 1
   其他the catalyst was removed
2. 2
   workup.DISTILLATIONthe solvent was then distilled off
3. 3
   其他The residue was crystallized from ethanol

实验过程

After a mixture consisting of 1-benzyl-4-(2-quinolylcarbonyl)piperazine hydrochloride (18.81 g, 51.1 mmol), 10% palladium-charcoal catalyst (3.00 g) and water (150 ml) was stirred for 3 hours at a bath temperature of 70° C. under a hydrogen gas stream, the catalyst was removed and the solvent was then distilled off. The residue was crystallized from ethanol, whereby 11.03 g of the title compound were obtained as colorless prisms (yield: 77.7%).

来源