反应 #452484

反应方程式

1-bromo-3-chloropropane

1-(2-quinolylmethyl)piperazine

potassium carbonate

→

title compound

收率 65.7%

1-(3-chloropropyl)-4-(2-quinolylmethyl)piperazine

收率 65.7%

溶剂

acetone

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度under reflux
3. 3
   其他insoluble matter was removed
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   workup.DISSOLUTIONThe oil residue was dissolved in chloroform

实验过程

A mixture consisting of 1-(2-quinolylmethyl)piperazine (21.75 g, 95.7 mmol), potassium carbonate (19.90 g, 144 mmol), 1-bromo-3-chloropropane (16.57 g, 105 mmol) and acetone (250 ml) was heated under reflux and stirring for 20 hours, insoluble matter was removed and the solvent was distilled off. The oil residue was dissolved in chloroform and the resulting solution was then subjected to chromatography on a silica gel column (developer: chloroform/methanol=100/1), whereby 19.10 g of the title compound were obtained as a yellow oil (yield: 65.7%).

来源