反应 #452483

反应方程式

acetone

7-hydroxy-3,4-dihydro-2H-1,4-benzothiazin-3-one

1bromo-3-chloropropane

→

title compound

收率 50.4%

7-(3-chloropropoxy)-3,4-dihydro-2H-1,4-benzothiazin-3-one

收率 50.4%

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度under reflux
3. 3
   过滤insolube matter was filtered off
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
5. 5
   其他to purify the same, and
6. 6
   其他was then recrystallized from acetone

实验过程

After a mixture consisting of 7-hydroxy-3,4-dihydro-2H-1,4-benzothiazin-3-one (1.812 g, 10 mmol), 1bromo-3-chloropropane (2.362 g, 15 mmol), potassium carbate (4.146 g, 30 mmol) and acetone (40 mmol) was heated under reflux and stirring for 24 hours, insolube matter was filtered off, and the solvent was distilled off under reduced pressure. The residue was subjected to chromatography on a silica gel column (developer: chloroform) to purify the same, and was then recrystallized from acetone. The title compound (1.300 g) was obtained as yellow leaflets (yield: 50.4%).

来源