反应 #452482

反应方程式

homopiperazine

2-chloromethyl-quinoline hydrochloride

triethyl-amine

→

title compound

收率 39.3%

1-(2-quinolylmethyl)homopiperazine

收率 39.3%

溶剂

ethanol

反应条件

后处理

1. 1
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
2. 2
   workup.ADDITIONWater was added to the residue
3. 3
   洗涤After the resulting mixture was washed three times with ethyl ether, sodium chloride
4. 4
   workup.ADDITIONwas added to the water layer
5. 5
   萃取followed by extraction four times with chloroform-methanol (2:1)
6. 6
   洗涤The extract was washed with an aqueous solution of sodium chloride
7. 7
   干燥dried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

实验过程

After a mixture consisting of 2-chloromethyl-quinoline hydrochloride (63.16 g, 295 mmol), triethyl-amine (29.85 g, 295 mmol), homopiperazine (50.08 g, 591 mmol) and ethanol (600 ml) was stirred at room temperature for 2 days, the solvent was distilled off under reduced pressure. Water was added to the residue. After the resulting mixture was washed three times with ethyl ether, sodium chloride was added to the water layer, followed by extraction four times with chloroform-methanol (2:1). The extract was washed with an aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, whereby 28.00 g of the title compound were obtained as a yellow oil (yield: 39.3%).

来源