反应 #452479

反应方程式

product

4-(2-Methoxyphenyl)-1-(3-aminopropyl)piperazine

2-chloropyridine

→

product

收率 13.4%

4-(2-Methoxyphenyl)-1-(3-(pyridin-2-yl)aminopropyl)piperazine

收率 13.4%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   温度After cooling
2. 2
   洗涤washed with aqueous NaOH (3×50 ml)
3. 3
   干燥dried (MgSO4)
4. 4
   其他evaporated in vacuo
5. 5
   其他The residue was purified by chromatography [alumina; ethyl acetate-toluene (1:4)]

实验过程

The product of Example 27 (3.9 g, 16 mmol) and 2-chloropyridine (1.82 g, 16 mmol) were heated at 160° C. in a sealed vessel for 6 h. After cooling, the residue was taken up into CH2Cl2 (50 ml) washed with aqueous NaOH (3×50 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by chromatography [alumina; ethyl acetate-toluene (1:4)] to give the product (0.7 g) as a brown oil.

来源