反应 #452477

ord-22fea30183c04db69593e05118e5f118

反应方程式

C=CC#N
acrylonitrile
COc1ccccc1N1CCNCC1
2-methoxyphenylpiperazine
COc1ccccc1N1CCN(CCC#N)CC1
product
收率 91.7%
COc1ccccc1N1CCN(CCC#N)CC1
3-[4-(2-Methoxyphenyl)piperazin-1-yl]propionitrile
收率 91.7%

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他the solvent was evaporated in vacuo

实验过程

A solution of acrylonitrile (1.06 g, 20 mmol) in ethanol (50 ml) was added to a stirred solution of 2-methoxyphenylpiperazine (3.84 g, 20 mmol) in ethanol (100 ml). After 18 h, the solvent was evaporated in vacuo to give the product (4.5 g) as a white solid.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06127357uspto-grants-2000_10