反应 #452476

反应方程式

Ammonium formate

product

1-[4-Benzyl-(1-piperazinyl)]isoquinoline

→

product

1-[1-Piperazinyl]isoquinoline

溶剂

methanol

Methanol

反应条件

后处理

1. 1
   温度was heated at 75° C. for 16 h
2. 2
   过滤the mixture filtered through Kieselguhr
3. 3
   浓缩concentrated in vacuo

实验过程

Ammonium formate (1.01 g, 16.0 mmol) and 10% Pd/C 42.5 mg, 0.4 mmol, 10 mol%) were added successively to a stirred solution of the product of Example 21 (1.23 g, 4.06 mmol) in methanol (4 ml). The mixture was stirred at room temperature for 6 h and was heated at 75° C. for 16 h. Methanol (40 ml) was added and the mixture filtered through Kieselguhr, and concentrated in vacuo to give the product as a pale yellow oil.

来源