反应 #452475

反应方程式

water

1-chloroisoquinoline

1-benzylpiperazine

N,N-diisopropylethylamine

→

product

收率 40.6%

1-[4-Benzyl-(1-piperazinyl)]isoquinoline

收率 40.6%

溶剂

DMF

DMF

反应条件

后处理

1. 1
   温度The yellow solution was heated at 110° C. for 7 h
2. 2
   萃取extracted with ether (2×50 ml)
3. 3
   干燥The extracts were dried (Na2SO4)
4. 4
   浓缩concentrated in vacuo
5. 5
   其他The residue was chromatographed (SiO2 ; ethyl acetate)

实验过程

A solution of 1-chloroisoquinoline (1.64 g 10 mmol) in dry DMF (5 ml) was added to a stirred solution of 1-benzylpiperazine (1.85 g, 10.5 mmol) and N,N-diisopropylethylamine (2 ml, 1.5 g, 11.5 mmol) in dry DMF (5 ml) under Ar at room temperature. The solution was stirred at room temperature for 17 h. The yellow solution was heated at 110° C. for 7 h, treated with water (100 ml) and extracted with ether (2×50 ml). The extracts were dried (Na2SO4) and concentrated in vacuo. The residue was chromatographed (SiO2 ; ethyl acetate) to give the product (1.233 g).

来源