反应 #452474

反应方程式

product

2,3-Dihydro-1,4-benzodioxin-5-amine

bis(2-chloroethyl)amine hydrochloride

→

product

收率 90.8%

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine

收率 90.8%

溶剂

chlorobenzene

反应条件

后处理

1. 1
   温度under reflux for 24 h
2. 2
   其他evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe white solid was dissolved in aqueous sodium hydroxide (100 ml)
4. 4
   萃取extracted into ethyl acetate (3×50 ml)
5. 5
   干燥The extracts were dried (MgSO4)
6. 6
   其他evaporated in vacuo

实验过程

The solution of the product of example 13 (1.50 g, 0.010 mol) and bis(2-chloroethyl)amine hydrochloride (1.77 g 0.01 mol) in chlorobenzene (20 ml) was heated under reflux for 24 h, cooled to room temperature and evaporated in vacuo. The white solid was dissolved in aqueous sodium hydroxide (100 ml) and extracted into ethyl acetate (3×50 ml). The extracts were dried (MgSO4) and evaporated in vacuo to give the product (2.00 g).

来源