反应 #452473

反应方程式

Ammonium formate

product

5-Nitro-2,3-dihydro-1,4-benzodioxin

→

product

收率 74.0%

2,3-Dihydro-1,4-benzodioxin-5-amine

收率 74.0%

溶剂

methanol

反应条件

后处理

1. 1
   过滤the mixture was filtered
2. 2
   其他evaporated in vacuo
3. 3
   其他triturated with acetonitrile
4. 4
   其他The residue was purified by chromatography (silica; ether)

实验过程

Ammonium formate (3.40 g, 0.054 mol) and 10% palladium on charcoal (1.44 g) were added to a stirred solution of the product of example 12 (2.45 g, 0.0135 mol) in methanol (15 ml). After the considerable effervescence had ceased, the mixture was filtered, evaporated in vacuo and triturated with acetonitrile. The residue was purified by chromatography (silica; ether) to give the product (1.51 g).

来源