反应 #452471

反应方程式

Cyclohexanecarbonyl chloride

2-aminothiazole

di-isopropylethylamine

→

product

收率 72.8%

N-(2-thiazolyl)cyclohexanecarboxamide

收率 72.8%

溶剂

dichloromethane

反应条件

后处理

1. 1
   洗涤washed with 1 N
2. 2
   干燥HCl (2×50 ml) and 1 N--NaOH (2×50 ml), dried (MgSO4)
3. 3
   其他evaporated in vacuo

实验过程

Cyclohexanecarbonyl chloride (4.38 g, 30 mmol) was added dropwise to a solution of 2-aminothiazole (3.00 g, 30 mmol) and di-isopropylethylamine (3.87 g, 30 mmol) in dichloromethane (50 ml) at 0° C. The mixture was warmed to room temperature, stirred for 18 h, washed with 1 N--HCl (2×50 ml) and 1 N--NaOH (2×50 ml), dried (MgSO4), and evaporated in vacuo to give the product (4.59 g) as white crystals.

来源