反应 #452467

反应方程式

propane-1,3-diamine

tetrahydrofuran

pyridine

→

N-(quinolin-2-yl)propane-1,3-diamine

收率 82.0%

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   温度The reaction mixture was heated
3. 3
   温度at reflux temperature for 18 h
4. 4
   其他To the cooled reaction mixture
5. 5
   过滤the precipitate was filtered off
6. 6
   洗涤washed with tetrahydrofuran (2×50 ml)
7. 7
   其他The solvent was evaporated in vacuo
8. 8
   workup.DISTILLATIONthe residue purified by distillation at 154° C.

实验过程

To a solution of propane-1,3-diamine (65.1 ml, 0.764 mol) in dry pyridine (25 ml) kept under an atmosphere of nitrogen 2-chloro-quinoline (25 g, 0.153 mol) was added. The reaction mixture was heated at reflux temperature for 18 h. To the cooled reaction mixture was added tetrahydrofuran (100 ml) and the precipitate was filtered off and washed with tetrahydrofuran (2×50 ml). The solvent was evaporated in vacuo and the residue purified by distillation at 154° C. and 2.5×10-2 mbar affording 25.34 g (82%) of N-(quinolin-2-yl)propane-1,3-diamine as a crystallising oil.

来源