反应 #452462

反应方程式

sodium hydride

4-bromobenzylbromide

N-(pyridin-2-yl)propane-1,3-diamine

→

N-(4-bromobenzyl)-N-(pyridin-2-yl)propane-1,3-diamine

收率 86.8%

溶剂

dimethylsulfoxide

dimethylsulfoxide

dimethylsulfoxide

反应条件

后处理

1. 1
   workup.STIRRINGThe reaction mixture was stirred for 48 h at room temperature
2. 2
   workup.ADDITIONThe reaction mixture was poured onto ice water (500 ml)
3. 3
   萃取extracted with ethyl acetate (3×250 ml)
4. 4
   洗涤The combined organic extracts were washed with water (3×150 ml)
5. 5
   干燥dried (MgSO4)
6. 6
   过滤filtered
7. 7
   其他the solvent evaporated in vacuo
8. 8
   洗涤The residue (40.56 g) was washed with n-heptane (30 ml) which

实验过程

To a mixture of sodium hydride (5.86 g, 60% dispersion in mineral oil, 0.1415 mol) in dry dimethylsulfoxide (250 ml) was slowly added a solution of N-(pyridin-2-yl)propane-1,3-diamine (20 g, 0.1323 mol) in dry dimethylsulfoxide (50 ml) at room temperature under an atmosphere of nitrogen. The reaction mixture was stirred until gas evolution was ceased. A solution of 4-bromobenzylbromide (36.09 g, 0.1415 mol) in dry dimethylsulfoxide (100 ml) was slowly added at room temperature. The reaction mixture was stirred for 48 h at room temperature. The reaction mixture was poured onto ice water (500 ml) and extracted with ethyl acetate (3×250 ml). The combined organic extracts were washed with water (3×150 ml), dried (MgSO4), filtered and the solvent evaporated in vacuo. The residue (40.56 g) was washed with n-heptane (30 ml) which afforded 36.77 g of crude N-(4-bromobenzyl)-N-(pyridin-2-yl)propane-1,3-diamine. 20 g crude product was purified by column chromatography on silica gel (900 ml) using dichloremethane/methanol/triethylamine 9:0.5:0.5 as eluent affording 13.75 g (70%) of N-(4-bromobenzyl)-N-(pyridin-2-yl)propane-1,3-diamine as an oil.

来源