反应 #452447

反应方程式

Potassium carbonate

3,7-dimethyl-1,6-octadien-3-yl 3-oxo-butyrate

benzyl chloride

→

desired compound

3,7-dimethyl-1,6-octadien-3-yl 3-oxo-2-benzylbutyrate

溶剂

acetone

反应条件

后处理

1. 1
   其他fitted with a magnetic stirrer, condenser and argon inlet
2. 2
   温度The mixture is heated
3. 3
   温度to reflux for 18 h
4. 4
   过滤The cooled mixture is filtered
5. 5
   浓缩concentrated by rotary evaporation
6. 6
   其他The resulting oil is purified on silica gel

实验过程

Potassium carbonate (3.92 g, 0.028 mol), 3,7-dimethyl-1,6-octadien-3-yl 3-oxo-butyrate (4.80 g, 0.030 mol), benzyl chloride (4.80 g, 0.038 mol) and acetone (15 mL) are placed in a 50 mL round-bottomed flask fitted with a magnetic stirrer, condenser and argon inlet. The mixture is heated to reflux for 18 h. The cooled mixture is filtered and concentrated by rotary evaporation. The resulting oil is purified on silica gel to yield the desired compound. Structure is confirmed by thin layer chromatography and 1H and 13C NMR.

来源