反应 #452432

反应方程式

1,4-cyclohexanedione mono-ethylene ketal

dimethylamine

sodium cyanoborohydride

→

title compound

收率 85.0%

4-dimethylamino-1-cyclohexanone ethylene ketal

收率 85.0%

溶剂

acetic acid

acetic acid

反应条件

后处理

1. 1
   workup.STIRRINGthe reaction stirred for an additional hour at ambient
2. 2
   workup.STIRRINGstirred 18 hours at ambient
3. 3
   其他The volatiles were removed under reduced pressure
4. 4
   workup.DISSOLUTIONthe residue dissolved in cold 5% tartaric acid solution
5. 5
   萃取This aqueous phase was extracted well with dichloromethane
6. 6
   浓缩concentrated under reduced pressure

实验过程

To a solution of 5.0 gm (32 mMol) 1,4-cyclohexanedione mono-ethylene ketal and 10.80 gm (240 mMol) dimethylamine were added 2.0 mL acetic acid and the mixture was stirred at 0° C. for 1.5 hours. To this solution were then added 3.62 gm (58 mMol) sodium cyanoborohydride and the reaction stirred for an additional hour at ambient. The pH of the reaction mixture was adjusted to ~7 with 16 mL acetic acid and stirred 18 hours at ambient. The volatiles were removed under reduced pressure and the residue dissolved in cold 5% tartaric acid solution and then the aqueous phase was made basic with 5N sodium hydroxide. This aqueous phase was extracted well with dichloromethane. These organic extracts were combined and concentrated under reduced pressure to give 5.04 gm (85%) of the title compound as an oil.

来源