反应 #452426

反应方程式

2-iodopropane

2-(4-pyrazolyl)-1-ethanol

sodium carbonate

→

title compound

收率 26.0%

2-(1-isopropyl-1H-pyrazol-4-yl)-1-ethanol

收率 26.0%

溶剂

dimethylformamide

dimethylformamide

反应条件

后处理

1. 1
   温度The reaction mixture was then cooled to ambient and
2. 2
   浓缩then concentrated under reduced pressure
3. 3
   其他The residue was partitioned between water and dichloromethane
4. 4
   洗涤The organic phase was then washed with water
5. 5
   干燥was then dried over sodium sulfate
6. 6
   浓缩The remaining organics were concentrated under reduced pressure

实验过程

To a solution of 1.0 gm (9.0 mMol) 2-(4-pyrazolyl)-1-ethanol in 36 mL dimethylformamide were added 2.38 gm (22.5 mMol) sodium carbonate followed by the dropwise addition of a solution of 0.89 mL (9.0 mMol) 2-iodopropane in 8 mL dimethylformamide. The reaction mixture was heated to 100° C. for 18 hours. The reaction mixture was then cooled to ambient and then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. The organic phase was then washed with water followed by saturated aqueous sodium chloride and was then dried over sodium sulfate. The remaining organics were concentrated under reduced pressure to give 0.36 gm (26.0%) of the title compound as a brown oil.

来源