反应 #452423

反应方程式

water

4-fluorobenzoyl chloride

4-nitroaniline

pyridine

→

N-(4-fluorobenzoyl)-4-nitroaniline

收率 91.3%

溶剂

dichloromethane

反应条件

后处理

1. 1
   workup.WAITfor an hour at room temperature
2. 2
   其他the solid which formed
3. 3
   过滤was collected by filtration
4. 4
   洗涤The filter cake was washed with hexane (80 mL)
5. 5
   其他was then dried under vacuum at 60° C.

实验过程

To a stirred suspension of 19.83 gm (143.56 mMol) 4-nitroaniline in 150 mL dichloromethane and 12.9 mL (159.5 mMol) pyridine at 0° C. were slowly added 24.5 gm (154.8 mMol) 4-fluorobenzoyl chloride. The reaction mixture was then stirred for 15 minutes at 0° C., at which time the reaction mixture became homogeneous, and then for an hour at room temperature. To this mixture were then added 100 mL water and the solid which formed was collected by filtration. The filter cake was washed with hexane (80 mL) followed by water (100 mL) and it was then dried under vacuum at 60° C. to give 34.1 gm (91%) N-(4-fluorobenzoyl)-4-nitroaniline.

来源