反应 #452180

反应方程式

Ammonium persulphate

4-dimethylaminomethylpyridine

methanol

sulphuric acid

→

4-dimethylaminomethyl-2-hydroxymethylpyridine

溶剂

water

water

water

反应条件

后处理

1. 1
   温度The resulting solution was refluxed for 2 hours
2. 2
   workup.DISTILLATIONthe methanol was distilled off
3. 3
   萃取extracted with chloroform

实验过程

Ammonium persulphate (102.7 g) in water (200 ml) was added over 40 minutes to a refluxing solution of 4-dimethylaminomethylpyridine (40.86 g), methanol (450 ml), water (210 ml) and concentrated sulphuric acid (30 ml). The resulting solution was refluxed for 2 hours, water (300 ml) was added and the methanol was distilled off. The cooled solution was basified and extracted with chloroform to give 4-dimethylaminomethyl-2-hydroxymethylpyridine (19.65 g) b.p. 92°-120°/0.06 mm Hg.

来源