反应 #45207

反应方程式

2-methylbenzothiazole

1,4-butane sultone

→

Compound 1

收率 98.1%

4-(Sulfobutyl)-2-methylbenzothiazole

收率 98.1%

反应条件

后处理

1. 1
   温度to cool to room temperature
2. 2
   其他the resulting mass was triturated with ethyl acetate (50 ml) until a gray solid
3. 3
   其他separated
4. 4
   其他The solid was collected by centrifugation
5. 5
   洗涤washed with ethyl acetate
6. 6
   其他dried under vacuum

实验过程

A mixture of 2-methylbenzothiazole (1.49 g, 10 mmol) and 1,4-butane sultone (4.0 g, 30 mmol) was heated in a pressure tube at 130-140° C. for 3 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (50 ml) until a gray solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 2.8 g (96%) of Compound 1.

来源