反应 #44954

反应方程式

Pseudomonic acid

potassium hydroxide

calcium chloride

→

Mupirocin Calcium

溶剂

ethanol

反应条件

后处理

1. 1
   过滤the solution was filtered
2. 2
   其他to remove potassium chloride (0.51 g)
3. 3
   其他The ethanol was subsequently evaporated at reduced pressure
4. 4
   其他to give a solid, white foam
5. 5
   其他The product was dried for 12 hours at 45° C. under vacuum

实验过程

Pseudomonic acid (5.00 g, 10 mmole) was dissolved in ethanol (20 ml), ethanolic solution of potassium hydroxide (0.56 g, 10 mmole potassium hydroxide and 10 ml ethanol) and ethanolic solution of calcium chloride (0.56 g, 5.0 mmole calcium chloride and 10 ml ethanol) were added to the mixture. The mixture was stirred for 1 hour and the solution was filtered to remove potassium chloride (0.51 g). The ethanol was subsequently evaporated at reduced pressure to give a solid, white foam. The product was dried for 12 hours at 45° C. under vacuum. The product had a mass of 4.38 grams. Assay: 99.1%, water: 2.36% [total impurity: 2.44%, highest impurity: 1.10% different method than the assay].

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