反应 #44952

反应方程式

Pseudomonic acid

Calcium oxide

pseudomonic acid

→

Mupirocin calcium dihydrate

收率 62.0%

溶剂

isobutyl acetate

water

反应条件

后处理

1. 1
   其他the phases were separated
2. 2
   workup.DISTILLATIONThe volume of the aqueous phase was reduced to 15 ml by vacuum distillation
3. 3
   workup.STIRRINGAfter stirring for 2 hours
4. 4
   过滤the crystalline product was filtered
5. 5
   洗涤washed with cooled water (5 ml)
6. 6
   其他The product was dried in an air
7. 7
   其他at RT

实验过程

Pseudomonic acid was dissolved in isobutyl acetate (130 ml). Calcium oxide (0.29 g) was suspended in water (32 ml) and added to the solution of pseudomonic acid. The mixture was stirred for 2 hours, and the phases were separated. The volume of the aqueous phase was reduced to 15 ml by vacuum distillation. The mixture was cooled to 5° C. After stirring for 2 hours, the crystalline product was filtered and washed with cooled water (5 ml). The product was dried in an air circulated oven at RT. Mupirocin calcium dihydrate (3.3 g, 62%) was obtained.

来源