反应 #4494

反应方程式

butyramide

1.3-dichloroacetone

sodium bicarbonate

→

4-chloromethyl-2-propyloxazole

溶剂

water

反应条件

后处理

1. 1
   温度After cooling
2. 2
   萃取extracted with ethyl ether
3. 3
   洗涤The extract was washed with water
4. 4
   干燥dried (MgSO4)
5. 5
   浓缩concentrated
6. 6
   其他The residue was purified by chromatography on silica gel with acetone-hexane (1:9)

实验过程

A mixture of butyramide (19.88 g) and 1.3-dichloroacetone (24.14 g) was heated at 130° C. for 1.5 hours. After cooling, the mixture was diluted with water, neutralized with aqueous sodium bicarbonate solution and extracted with ethyl ether. The extract was washed with water, dried (MgSO4) and concentrated. The residue was purified by chromatography on silica gel with acetone-hexane (1:9) to yield 4-chloromethyl-2-propyloxazole as an oil (10.70 g 35.3%). NMR (CDCl3)δ: 0.97 (3H, t, J=7.5 Hz), 1.79 (2H, sext, J=7.5 Hz), 2.72 (2H, t, J=7.5 Hz), 4.47 (2H, s), 7.53 (1H, s).

来源