反应 #44761

反应方程式

1-(2-chloroethoxy)-4-(benzyl)benzene

sodium iodide

water

→

1-(2-iodoethoxy)-4-(benzyl)benzene

收率 72.9%

溶剂

2-butanone

反应条件

后处理

1. 1
   温度at reflux for 16 hours
2. 2
   温度After cooling
3. 3
   萃取The mixture was extracted with ethyl acetate
4. 4
   洗涤The organic layer was washed with brine
5. 5
   干燥dried over sodium sulfate
6. 6
   浓缩concentrated under reduced pressure

实验过程

A solution of 1-(2-chloroethoxy)-4-(benzyl)benzene (734 mg, 2.97 mmol) and sodium iodide (1.78 g, 11.9 mmol) in 2-butanone (30 mL) was heated at reflux for 16 hours. After cooling, water was added. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. Flash chromatography gave 732 mg of 1-(2-iodoethoxy)-4-(benzyl)benzene, 1H NMR (300 MHz, CDCl3) δ 7.29 (dd, 2H), 7.19 (dd, 1H), 7.18 (d, 2H), 7.11 (d, 2H), 6.84 (d, 2H), 4.23 (t, 2H), 3.94 (s, 2H), 3.41 (t, 2H) ppm.

来源