反应 #4476

反应方程式

water

potassium carbonate

product

1,2,3,9-Tetrahydro-6-methoxy-4H-carbazol-4-one

Dimethyl sulphate

→

title compound

收率 78.2%

1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

收率 78.2%

溶剂

acetone

反应条件

后处理

1. 1
   温度the mixture was heated
2. 2
   温度to reflux for 4 h
3. 3
   过滤the resulting precipitate filtered off

实验过程

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

来源