反应 #44697

反应方程式

2,6-difluorobenzonitrile

potassium carbonate

3-chloro-4-hydroxyaniline

→

2-(4-Amino-2-chlorophenoxy)-6-fluorobenzonitrile

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度the mixture is heated
2. 2
   温度at reflux for 45 min
3. 3
   过滤The mixture is filtered
4. 4
   洗涤the filtercake is washed with ethyl acetate and DCM
5. 5
   其他The solvent is removed under reduced pressure

实验过程

1.00 g (7.19 mmol) of 2,6-difluorobenzonitrile is initially charged in 10 ml of acetonitrile. 1.99 g (14.4 mmol) of potassium carbonate and 1.03 g (7.19 mmol) of 3-chloro-4-hydroxyaniline are added, and the mixture is heated at reflux for 45 min. The mixture is filtered and the filtercake is washed with ethyl acetate and DCM. The solvent is removed under reduced pressure and the residue is by column chromatography (silica gel 60, gradient column: mobile phase: DCM:petroleum ether=2:1, then DCM).

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