反应 #44608

反应方程式

Trifluoroacetic acid

methylene chloride

[(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

sodium hydrogencarbonate

→

title compound

收率 91.1%

(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propylamine

收率 91.1%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   其他The organic layer was separated
2. 2
   洗涤washed with a saturated sodium hydrogencarbonate aqueous solution
3. 3
   浓缩Then, the organic layer was concentrated under reduced pressure

实验过程

Trifluoroacetic acid (0.5 mL) was added to a methylene chloride solution (2 mL) of [(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester (370 mg). This reaction solution was stirred at room temperature for 11 hr. To this reaction solution, a saturated sodium hydrogencarbonate aqueous solution and ethyl acetate were added. The organic layer was separated, washed with a saturated sodium hydrogencarbonate aqueous solution and then with saturated saline. Then, the organic layer was concentrated under reduced pressure to give 275 mg of the title compound. The physical property values of this compound were as follows:

来源