反应 #44525

反应方程式

4-chloro-2-methylsulfanylpyrimidine

ammonia

→

2-(methylsulfanyl)-4-pyrimidinamine

溶剂

methanol

反应条件

后处理

1. 1
   温度cooled
2. 2
   浓缩concentrated
3. 3
   workup.ADDITIONtreated with water
4. 4
   萃取extracted with ethyl acetate
5. 5
   洗涤The extract was washed with brine
6. 6
   干燥dried over anhydrous sodium sulfate
7. 7
   浓缩concentrated
8. 8
   其他The concentrate was triturated with ethyl ether
9. 9
   过滤filtered

实验过程

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

来源