反应 #44518

反应方程式

6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

3-methoxyaniline

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title product

收率 80.0%

6-(2-(3-methoxyphenylamino)pyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

收率 80.0%

溶剂

DMF

反应条件

后处理

1. 1
   萃取subjected to extraction with ethyl acetate
2. 2
   workup.ADDITIONThen water was added
3. 3
   萃取the mixture was subjected to extraction with ethyl acetate
4. 4
   洗涤The organic layer was washed with water and brine sequentially
5. 5
   干燥dried over anhydrous Na2SO4
6. 6
   浓缩concentrated
7. 7
   其他The resulting residue was purified by column chromatography

实验过程

6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide (0.1 mmol) and 3-methoxyaniline (0.1 mmol) were dissolved in 0.5 ml DMF. To this was added p-TsOH monohydrate (0.2 mmol). The reaction mixture was stirred at 60° C. for 5 hours, and subjected to extraction with ethyl acetate. Then water was added and the mixture was subjected to extraction with ethyl acetate. The organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4, and concentrated. The resulting residue was purified by column chromatography to provide the title product in a yield of 80%.

来源