反应 #44498

反应方程式

product

9-Oxo-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester

ammonium acetate

NaBH3CN

→

9-Amino-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester

溶剂

methanol

反应条件

后处理

1. 1
   其他The solvent was then evaporated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane
3. 3
   洗涤washed with water, NaHCO3 solution, and brine
4. 4
   干燥and dried (Na2SO4)
5. 5
   过滤After filtration and evaporation of the solvent
6. 6
   其他the amine was used without further purification

实验过程

The product of Example 7A (2.03 g, 10.38 mmol) was stirred at room temperature in the presence of ammonium acetate (8 g, 103.8 mmol) and NaBH3CN (3.3 g, 51.9 mmol) in methanol (30 mL) for twelve hours at 23° C. The solvent was then evaporated and the residue was dissolved in dichloromethane; washed with water, NaHCO3 solution, and brine; and dried (Na2SO4). After filtration and evaporation of the solvent, the amine was used without further purification.

来源