反应 #44453

反应方程式

Cs2CO3

phenol

Water

1,4-dibromo-2-nitrobenzene

→

crude compound

收率 108.8%

4-Bromo-2-nitro-1-phenoxybenzene

收率 108.8%

溶剂

THF

ethyl acetate

反应条件

后处理

1. 1
   温度The resulting mixture was heated
2. 2
   温度to reflux
3. 3
   workup.STIRRINGstirred overnight
4. 4
   温度at reflux
5. 5
   萃取followed by extraction with ethyl acetate (3×)
6. 6
   洗涤The combined organic layers were washed with water and brine
7. 7
   干燥dried (Na2SO4)
8. 8
   其他evaporated

实验过程

Cs2CO3 (4 g, 12.3 mmol) was added to a solution of phenol (1 g, 10.6 mmol) in 50 mL of THF under N2 atmosphere. After stirring for 15 min. 1,4-dibromo-2-nitrobenzene (2.81 g, 10 mmol) was added. The resulting mixture was heated to reflux and stirred overnight at reflux. Water and ethyl acetate were added, followed by extraction with ethyl acetate (3×). The combined organic layers were washed with water and brine, dried (Na2SO4) and evaporated to give the crude compound (3.2 g, 75%).

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