反应 #44362

反应方程式

Morpholine

[4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride

Water

→

sub-title compound

4-[[4-Bromo-2-(trifluoromethyl)phenyl]sulfonyl]morpholine

溶剂

DCM

反应条件

后处理

1. 1
   萃取the mixture was extracted with DCM
2. 2
   干燥The organic extracts were dried (MgSO4)
3. 3
   其他evaporated
4. 4
   其他purified by chromatography (silica, petrol-ether as eluent)

实验过程

Morpholine (1.1 ml) was added to a solution of [4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride (2.03 g) in DCM (7 ml) at 0° C. and stirred at 20° C. for 16 h. Water was added and the mixture was extracted with DCM. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound 2.10 g).

来源