反应 #44356

反应方程式

Triphenylphosphine

4-bromo-2-fluorobenzenesulfonyl chloride

water

→

sub-title compound

收率 92.2%

4-Bromo-2-fluorobenzenethiol

收率 92.2%

溶剂

THF

反应条件

后处理

1. 1
   其他The solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONthe residues dissolved in DCM
3. 3
   萃取extracted with 2M sodium hydroxide (twice)
4. 4
   洗涤The aqueous layers were washed with DCM
5. 5
   萃取extracted with ethyl acetate (thrice)
6. 6
   干燥These organic extracts were dried (MgSO4)
7. 7
   其他evaporated

实验过程

Triphenylphosphine was added portionwise to a solution of 4-bromo-2-fluorobenzenesulfonyl chloride (8.44 g) in THF (30 ml) at 0° C. After 15 min water was added and the colourless solution was stirred at 20° C. for 18 h. The solvent was removed in vacuo, the residues dissolved in DCM and extracted with 2M sodium hydroxide (twice). The aqueous layers were washed with DCM, combined, acidified (4M HCl) and extracted with ethyl acetate (thrice). These organic extracts were dried (MgSO4) and evaporated to give the sub-title compound (5.89 g).

来源