反应 #44233

反应方程式

methylhydrazine

ethyl pyruvate

MgSO4

→

desired product

收率 94.0%

ethyl 2-(2-methylhydrazono)propanoate

收率 94.0%

溶剂

CHCl3

CHCl3

反应条件

后处理

1. 1
   过滤the reaction mixture was filtered
2. 2
   浓缩The filtrate was concentrated under reduced pressure

实验过程

To a suspension of ethyl pyruvate (37.8 mL, 338 mmol) and MgSO4 (40.8 g, 339 mmol) in CHCl3 (500 mL) was added a solution of methylhydrazine (18.0 mL, 332 mmol) in CHCl3 (100 mL) at 0° C. The reaction mixture was warmed to room temperature. After stirring for 24 hours at room temperature, the reaction mixture was filtered. The filtrate was concentrated under reduced pressure to give 44 g (94%) of the desired product that was used directly without further purification.

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