反应 #4387

反应方程式

2-amino-3-hydroxypyridine

2-methylbenzyl chloride

→

2-amino-3-(2-methylbenzyloxy)pyridine

溶剂

sodium hydroxide

methylene chloride

反应条件

后处理

1. 1
   其他the organic layer was separated
2. 2
   萃取the aqueous layer was extracted with methylene chloride
3. 3
   洗涤The combined extracts were washed with saturated sodium chloride aqueous solution
4. 4
   干燥dried over magnesium sulfate
5. 5
   其他evaporated in vacuo
6. 6
   其他The crystalline residue was recrystallized from ethyl acetate

实验过程

To a mixture of 2-amino-3-hydroxypyridine (7 g) and Adogen 464 (Trademark: prepared by Aldrich Chemical Co.) (0.4 g) in 40% aqueous sodium hydroxide (32 ml) and methylene chloride (32 ml) was added 2-methylbenzyl chloride (8.42 ml) at ambient temperature. After being stirred for 24 hours, the organic layer was separated and the aqueous layer was extracted with methylene chloride. The combined extracts were washed with saturated sodium chloride aqueous solution, dried over magnesium sulfate, and evaporated in vacuo. The crystalline residue was recrystallized from ethyl acetate to give 2-amino-3-(2-methylbenzyloxy)pyridine (7.56 g).

来源