反应 #43820

反应方程式

2-Chlorobenzyl chloride

K2CO3

[5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

→

{5-[(2-Chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

溶剂

EtOAc

H2O

CH3CN

反应条件

后处理

1. 1
   过滤filtered through an Extrelut column
2. 2
   洗涤The column was washed with EtOAc
3. 3
   浓缩the filtrate was concentrated
4. 4
   其他The crude product was carried onto the next reaction without any further purification or characterization

实验过程

2-Chlorobenzyl chloride (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

来源