反应 #4377

反应方程式

iodine

1-(3-methoxyphenyl)butane-3-one

→

1-(2-iodo-5-methoxyphenyl)butane-3-one

收率 82.3%

溶剂

acetic acid

反应条件

后处理

1. 1
   其他The silver iodide was removed by filtration
2. 2
   洗涤washed with acetic acid
3. 3
   其他The filtrate was partitioned between ether and water
4. 4
   洗涤The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution
5. 5
   干燥The ether solution was dried with MgSO4
6. 6
   其他evaporated to dryness in vacuo

实验过程

Samples of iodine (42.4 g, 0.167 mole) and silver acetate (27.87 g, 0.167 mole) were added in portions to a solution of 29.8 g (0.167 mole) of 1-(3-methoxyphenyl)butane-3-one in 167 ml of glacial acetic acid. The mixture was stirred one hour. The silver iodide was removed by filtration and washed with acetic acid. The filtrate was partitioned between ether and water. The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution. The ether solution was dried with MgSO4 and evaporated to dryness in vacuo. There was obtained 41.8 g (82% yield) of oily 1-(2-iodo-5-methoxyphenyl)butane-3-one.

来源