反应 #43759

反应方程式

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-nitro-1-benzothiophene-2-carboxamide hydrochloride

→

title compound

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-amino-1-benzothiophene-2-carboxamide dihydrochloride

溶剂

tin(II) chloride

DMF

反应条件

后处理

1. 1
   其他The reaction mixture is purified by preparative HPLC
2. 2
   浓缩The product fractions are concentrated
3. 3
   workup.DISSOLUTIONdissolved in a mixture of methanol and 4M HCl in dioxane
4. 4
   浓缩again concentrated
5. 5
   其他dried under high vacuum

实验过程

83 mg (0.23 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-3-chloro-6-nitro-1-benzothiophene-2-carboxamide hydrochloride are dissolved in 1.5 ml of 2M tin(II) chloride solution in DMF and stirred at RT for 14 h. The reaction mixture is purified by preparative HPLC. The product fractions are concentrated, dissolved in a mixture of methanol and 4M HCl in dioxane, then again concentrated and dried under high vacuum. 53 mg (57.2% of theory) of the title compound are obtained.

来源