反应 #43745

反应方程式

HCl

5-nitro-1-benzothiophene-2-carboxylic acid

HATU

N,N-diisopropylethylamine

DMF

→

title compound

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-nitro-1-benzothiophene-2-carboxamide hydrochloride

溶剂

diethyl ether

反应条件

后处理

1. 1
   过滤filtered off
2. 2
   洗涤washed twice with dichloromethane
3. 3
   其他dried under high vacuum

实验过程

420 mg (1.88 mmol) of 5-nitro-1-benzothiophene-2-carboxylic acid, 374.7 mg (1.88 mmol) of R-3-aminoquinuclidine dihydrochloride, 858.6 mg (2.26 mmol) of HATU, 875.5 mg (6.78 mmol) of N,N-diisopropylethylamine and 2.0 ml of DMF are reacted according to the general procedure (variant B). The resulting precipitate is suspended in 1N HCl in diethyl ether, filtered off, washed twice with dichloromethane and dried under high vacuum. 523 mg (75.6% of theory) of the title compound are obtained.

来源