反应 #433606

反应方程式

3-Bromoaniline

4-chloro-6-nitroquinazoline

→

4-[(3-bromophenyl)amino]-6-nitroquinazoline

反应条件

实验过程

3-Bromoaniline is coupled with 4-chloro-6-nitroquinazoline, to produce 4-[(3-bromophenyl)amino]-6-nitroquinazoline, which is reduced thereafter to the corresponding 6-aminoquinazoline. The 4-[(3-bromophenyl)amino]-6-aminoquinazoline is then reacted with bistributyltin, using tetrakis(triphenylphosphine)palladium in THF solution as the reaction catalyst, as is described hereinbelow (see, iodine-124 labeled Compound 5). The stanylated quinazoline is then reacted with bromine-76 or bromine-77, in the presence of an oxidizing agent, to produce bromine-76 labeled or bromine-77 labeled 4-[(3-bromophenyl)amino]-6-aminoquinazoline, which is farther reacted with acryloyl chloride as described, to yield the final bromine-76 labeled or bromine-77 labeled product.

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