反应 #433601

反应方程式

3-Iodoaniline

4-chloro-6-nitroquinazoline

→

4-[(3-iodophenyl)amino]-6-nitroquinazoline

收率 78.0%

溶剂

iso-propylalcohol

反应条件

实验过程

3-Iodoaniline (12.57 grams, 57 mmol) was reacted with 4-chloro-6-nitroquinazoline (4 grams, 57 mmol), in iso-propylalcohol, as is described hereinabove, to give 4-[(3-iodophenyl)amino]-6-nitroquinazoline (5.99 grams, 78% yield), which was thereafter reacted (620 mg, 1.58 mmol) with hydrazine hydrate and Raney®Nickel, according to the procedure described hereinabove, to give 4-[(3-iodophenyl)amino]-6-aminoquinazoline (180 mg, 31% yield).

来源