反应 #433594

反应方程式

hydrazine hydrate

4-(phenylamino)-6-nitroquinazoline

iso-propylalcohol

→

4-(phenylamino)-6-aminoquinazoline

溶剂

ethanol water

反应条件

后处理

1. 1
   过滤The reaction mixture is filtered
2. 2
   其他evaporated
3. 3
   其他purified by silica gel chromatography

实验过程

A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.

来源