反应 #43330

反应方程式

2,5-dichloropyridine

potassium vinyltrifluoroborate

triethylamine

ethanol

→

title compound

收率 69.0%

5-chloro-2-vinylpyridine

收率 69.0%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   温度under reflux
2. 2
   洗涤by washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine
3. 3
   干燥drying over anhydrous sodium sulfate
4. 4
   浓缩Concentrating the solvent under reduced pressure
5. 5
   workup.DISTILLATIONthe resulting residue was distilled under reduced pressure (63° C., 8 mmHg)

实验过程

A mixture of 2,5-dichloropyridine (10.0 g), potassium vinyltrifluoroborate (10.86 g), dichloromethane complex (2.5 g) of dichloro-1,1′-bis(diphenylphosphino)-ferrocene palladium (II), triethylamine (14.13 mL) and ethanol (150 mL) was stirred overnight under reflux. After cooling the system to room temperature, ethyl acetate was added, followed by washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine and drying over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was distilled under reduced pressure (63° C., 8 mmHg) to provide the title compound (6.50 g, 69%).

来源