反应 #43061

反应方程式

Intermediate 1

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HCl dioxane

trimethylorthoformate

→

2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine

反应条件

后处理

1. 1
   其他The solvent was removed by rotary evaporation
2. 2
   其他to give product, which

实验过程

Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.

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