反应 #4303

反应方程式

Ether

benzyl 2-chloroethyl sulfone

isopropylamine

hydrogen chloride

→

white crystalline solid

收率 65.8%

N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

收率 65.8%

溶剂

methanol

反应条件

后处理

1. 1
   其他The solvent was removed in vacuo
2. 2
   其他the residue was partitioned between ether and dilute sodium hydroxide
3. 3
   干燥The ether solution was dried over magnesium sulfate
4. 4
   其他the solvent was removed in vacuo
5. 5
   其他to give an oil
6. 6
   其他a white solid precipitated

实验过程

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

来源