反应 #430046

反应方程式

Thionyl chloride

2-aminobutyric acid

ethanol

→

desired product

收率 97.0%

Ethyl 2-aminobutyrate hydrochloride

收率 97.0%

反应条件

后处理

1. 1
   workup.ADDITIONWhen addition
2. 2
   过滤the resulting precipitate filtered off
3. 3
   洗涤washed with methyl t-butyl ether

实验过程

Thionyl chloride (1.25 moles) was added to a solution of 2-aminobutyric acid (1 mole) in SD12A3 (95% ethanol/5% toluene) at a temperature of <5° C. When addition was complete, the mixture was stirred at 27° C. for 16 hours and the resulting precipitate filtered off and washed with methyl t-butyl ether to give the desired product as a white solid (97% yield).

来源