反应 #42857

反应方程式

2,2-dimethylglutaric acid

urea

→

3,3-dimethylpiperidin-2,6-dione

收率 86.2%

溶剂

water

反应条件

后处理

1. 1
   温度the mixture was cooled to near room temperature
2. 2
   萃取The mixture was extracted with ethyl acetate three times
3. 3
   洗涤The organic layers were washed with a saturated sodium chloride aqueous solution
4. 4
   干燥dried over anhydrous magnesium sulfate
5. 5
   浓缩concentrated

实验过程

The mixture of 10 g of 2,2-dimethylglutaric acid and 37.5 g of urea was stirred for 8 hours at 160° C. Into the reaction mixture was added water at 100° C., and the mixture was cooled to near room temperature. The mixture was extracted with ethyl acetate three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 7.6 g of 3,3-dimethylpiperidin-2,6-dione.

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