反应 #427397

反应方程式

3-chloro-5-(trifluoromethyl)picolinaldehyde

hydroxylamine hydrochloride

pyridine

→

3-chloro-5-(trifluoromethyl)picolinaldehyde oxime

溶剂

ethyl acetate

water

ethanol

反应条件

后处理

1. 1
   洗涤The organic layer was washed with brine, water
2. 2
   干燥dried over anhydrous MgSO4
3. 3
   浓缩concentrated en vacuo
4. 4
   其他to give a solid
5. 5
   其他that was carried onto the next step without further purification

实验过程

A solution of 3-chloro-5-(trifluoromethyl)picolinaldehyde (1.0 eq.), hydroxylamine hydrochloride (5.0 eq.), and pyridine (4.0 eq.) in ethanol was heated to 95° C. and stirred for 1 hour. The reaction was cooled to room temperature and diluted with ethyl acetate and water. The organic layer was washed with brine, water, dried over anhydrous MgSO4, and concentrated en vacuo to give a solid that was carried onto the next step without further purification.

来源