反应 #4262

反应方程式

Thymidine

N-(2-chloro-1,1,2-trifluoroethyl)diethylamine

ethanol

→

2,3'-anhydrothymidine

收率 60.3%

溶剂

DMF

反应条件

后处理

1. 1
   其他prepared
2. 2
   其他The product precipitated from this solution
3. 3
   过滤was filtered
4. 4
   过滤The ethanol supernatant was refrigerated then filtered

实验过程

Thymidine (85.4 g; 0.353 mol) was dissolved in 500 mL dry DMF (dimethyl formamide) and added to N-(2-chloro-1,1,2-trifluoroethyl)diethylamine (100.3 g; 0.529 mol) [prepared according to the method of D. E. Ayer, J. Med. Chem. 6, 608 (1963)]. This solution was heated at 70° C. for 30 minutes then poured into 950 mL ethanol with vigorous stirring. The product precipitated from this solution and was filtered. The ethanol supernatant was refrigerated then filtered to yield a total of 47.75 g (0.213 mol; 60.3%) of 2,3'-anhydrothymidine mp=228°-230° C.

来源