反应 #42560

反应方程式

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester

HCl

dioxane

methanol

→

solid

收率 106.0%

BOC-acetylene

收率 106.0%

反应条件

后处理

1. 1
   其他The volatiles were evaporated in vacuo
2. 2
   workup.ADDITIONDioxane (20 mL) was added
3. 3
   其他the mixture was evaporated in vacuo

实验过程

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester (2.34 g, 5.13 mmol) was treated with 4N HCl in dioxane (15.8 mL, 63.3. mmol). The resulting heterogeneous mixture was treated with methanol (10 mL) whereupon it became homogeneous over 30 min. The volatiles were evaporated in vacuo. Dioxane (20 mL) was added and the mixture was evaporated in vacuo to produce a white solid (2.33 g, 106%).

来源