反应 #42355

反应方程式

O-benzyl-N-(tert-butoxycarbonyl)homoserine

trimethylsilyldiazomethane

hexane

→

title compound

Methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate

溶剂

methanol benzene

反应条件

后处理

1. 1
   浓缩The solution is concentrated under reduced pressure

实验过程

To O-benzyl-N-(tert-butoxycarbonyl)homoserine (5.8 g, 18.9 mmol) in 20% methanol/benzene (72 mL) is added 2M trimethylsilyldiazomethane in hexane (12.3 mL, 24.5 mmol), and the reaction stirred at room temperature 1.5 h. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 324.2 [M+H]+.

来源